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Believe...Pick a stronger word than Hope...Cure.

Wake Forest Hsp70 research update...ALS

The Mulligan Lab is currently completing treatments of the SOD1G93A mouse model of ALS with four different doses of the Hsp70 protein and hopes to have the dose response study complete by the end of March/mid-April. With positive results (hopefully), our ALS scientists and clinicians will begin to design initial clinical trials in patients.

Department of Neurobiology and Anatomy

Medical Center Boulevard | Winston-Salem, NC 27157 |

February 17, 2017

Dear Mary Ann, Bob, and all Blazeman Warriors:

We would like to provide you with an update of the status of our research to develop recombinant heat shock protein (Hsp) 70 as a potential treatment for ALS.

As we reported previously, the results from an analysis of purity of our protein indicated that our preparations contain the full-length protein with little if any contamination of other proteins. Furthermore, the activity assays indicate that our in house protein’s activity is 30% greater than commercially available protein, or protein we made initially before making final modifications to the production protocol.

We are currently completing treatments of the SOD1G93A mouse model of ALS with four different doses of the protein. After consultation with our biostatisticians, 32 animals (16 male; 16 female)/dose are being treated in order for us to have significant power. As of today, we have approximately half of the animals treated, with a little less than 50% of the tissue processed. Our goal is to have the dose response study by the end of March/mid-April at the latest. Because these are blinded studies, we will not have results until all animals have been treated and experimental codes revealed. With positive results as we hope to obtain, our ALS scientists and clinicians will begin to design initial clinical trials in patients.

On behalf of all members of our ALS Center, we continue to express our gratitude to the Blazeman Foundation - because of this support we continue as Jon asked, we choose to "Believe...Pick a stronger word than Hope...Cure"

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Comment by blazedad on February 21, 2017 at 11:31pm

"The Bulldozer"..."the-blazeman's" description of what ALS eventually does to the one with ALS (pALS)...to their family...to friends...to all their lives...it's a "destroyer"...which can and must be stopped...it will be, the answer is through "research"...thank you all who are researching (ALS)...you also are "fighting the good fight", in the War On ALS...G-D bless, Jon, (alswarriorpoet-spirit). http://waronals.org/research/

Comment by blazedad on February 21, 2017 at 1:38pm

"Research"..."So bench to bedside"...(BF-ALS)...ALS since 1869, there hasn’t been any significant improvement in the treatment or cure of this disease...read this "researcher's words"...then you can understand...but must "believe"...bdad. Yes, we started in the early 2000’s with cells in a dish. Actually, in 1981 if you trace back to Mike’s original study. And, after all this, there is still no guarantee that it will work. This is really the hard part. When I start to think about how much we have done, and how much we have to still do- and how much it is going to cost- it is unnerving. No one else is doing this. But it’s times like this when I go look at the Blazeman Website ; ("Decision must be instant- Commitment must be total.")..."the-blazeman", (alswarriorpoet-spirit)...IM Finisher 2005

Comment by blazedad on February 21, 2017 at 1:32pm

"Believe...Pick a stronger word than Hope...Cure"

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